Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8399657 | 0.90 | KDM4E (0.42) | ACEMMEITGB3ITGA2BALDH1A1 | |
| SCHEMBL8398839 | 0.66 | PARP1 (0.41) | ITGB3ITGA2BALDH1A1MAPTKDM4E | |
| SCHEMBL8402362 | 0.66 | PARP1 (0.40) | ITGB3ITGA2BALDH1A1HDAC1HDAC6 | |
| SCHEMBL8518894 | 0.63 | BRD4 (0.31) | — | |
| SCHEMBL199254 | 0.62 | ACE (0.53) | ACEMMEKDM4EALOX15TSHR | |
| SCHEMBL30320121 | 0.62 | ACE (0.53) | ACEMMEKDM4EALOX15TSHR | |
| SCHEMBL3870683 | 0.62 | ACE (0.53) | ACEMMEKDM4EALOX15TSHR | |
| SCHEMBL8897186 | 0.62 | HDAC1 (0.35) | ALDH1A1MAPTKDM4EHDAC1HDAC7 | |
| SCHEMBL7444173 | 0.62 | ITGB3 (0.72) | ITGB3ITGA2B | |
| SCHEMBL8403456 | 0.61 | ITGB3 (0.40) | ACEMMEITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693636-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-02 | — | — | US | claimed |
| US-5939412-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |
| US-5693636-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-02 | — | — | US | disclosed |