Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.58 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8401315 | 0.78 | DDB1 (0.40) | CRBNDDB1KMT2AMEN1POLB | |
| SCHEMBL8399014 | 0.77 | DDB1 (0.55) | CRBNDDB1KMT2AMEN1ALDH1A1 | |
| SCHEMBL8402424 | 0.77 | DDB1 (0.44) | CRBNDDB1KMT2AMEN1POLB | |
| SCHEMBL8399413 | 0.77 | CRBN (0.41) | CRBNDDB1HTTKMT2AMEN1 | |
| SCHEMBL8521910 | 0.74 | CRBN (1.00) | CRBNDDB1HTTKMT2AGAA | |
| SCHEMBL8398464 | 0.74 | DDB1 (0.63) | CRBNDDB1KMT2AMEN1ALDH1A1 | |
| SCHEMBL8402252 | 0.71 | MMP12 (0.41) | CRBNDDB1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8402142 | 0.71 | THRB (0.50) | CRBNDDB1POLB | |
| SCHEMBL28733983 | 0.70 | CYP19A1 (0.57) | CRBNDDB1 | |
| SCHEMBL28733980 | 0.70 | CYP19A1 (0.57) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711283-B1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5618811-A | Tetrahydro-1H-benzazepinones and hexahydroazepinones as selective cholecystokinin-B receptor antagonists | PFIZER INC. (US) | 1997-04-08 | — | — | US | disclosed |