Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840499 | 1.00 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10HPGDMAPT | |
| SCHEMBL235785 | 0.87 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10HPGDKMT2A | |
| SCHEMBL9054019 | 0.87 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10HPGDKMT2A | |
| SCHEMBL27679077 | 0.85 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10HPGDKMT2A | |
| Ammonia Solution, Strong SCHEMBL27560423 | 0.85 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10HPGDKMT2A | |
| SCHEMBL335361 | 0.82 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10HPGDMAPT | |
| SCHEMBL23727368 | 0.81 | MAPT (0.35) | ALDH1A1LMNAHPGDMAPTRAB9A | |
| SCHEMBL13269391 | 0.81 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10HPGDKMT2A | |
| SCHEMBL10804777 | 0.80 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10HPGDMAPT | |
| SCHEMBL857612 | 0.80 | SMN1; SMN2 (0.45) | ALDH1A1LMNAHSD17B10HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143416-B2 | Alternative synthesis of renin inhibitors and intermediates thereof | NOVARTIS AG (CH) | 2012-03-27 | — | — | US | disclosed |
| US-20110137044-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | NOVARTIS AG (CH) | 2011-06-09 | — | — | US | disclosed |
| US-7910774-B2 | Alternative synthesis of renin inhibitors and intermediates thereof | NOVARTIS AG (CH) | 2011-03-22 | — | — | US | disclosed |
| EP-1789377-B1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | NOVARTIS AG (CH) | 2010-10-20 | — | — | EP | disclosed |
| EP-1978012-A1 | Alternative synthesis of renin inhibitors and intermediates thereof | Novartis AG (CH) | 2008-10-08 | — | — | EP | disclosed |
| US-20070208055-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | NOVARTIS AG (CH) | 2007-09-06 | — | — | US | disclosed |
| EP-1789377-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | Novartis AG (CH) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006024501-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | NOVARTIS AG (CH) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110137044-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | REN, ACE, AGT | ALDH1A1 934/4885LMNA 584/4885HSD17B10 432/4885 |
| US-20070208055-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | REN, ACE, AGT | ALDH1A1 954/4885LMNA 577/4885HSD17B10 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.