Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 17/20 | 0.48 |
| ▸ | CCKBR | P32239 | 14/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | MC1R | Q01726 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8402054 | 0.87 | CCKAR (0.47) | CCKARCCKBRALDH1A1MC4RMC1R | |
| SCHEMBL8401890 | 0.82 | CCKAR (0.53) | CCKARCCKBRMC4RMC1R | |
| SCHEMBL8803760 | 0.81 | CCKAR (0.62) | CCKARCCKBR | |
| SCHEMBL8405715 | 0.80 | CCKAR (0.51) | CCKARCCKBR | |
| SCHEMBL8404990 | 0.78 | CCKAR (0.55) | CCKARCCKBR | |
| SCHEMBL8806294 | 0.78 | CCKAR (0.52) | CCKARCCKBRALDH1A1 | |
| SCHEMBL8803122 | 0.78 | CCKAR (0.51) | CCKARCCKBR | |
| SCHEMBL8804860 | 0.78 | CCKAR (0.50) | CCKARCCKBR | |
| SCHEMBL8803663 | 0.77 | CCKAR (0.51) | CCKARCCKBR | |
| SCHEMBL8401840 | 0.77 | KMT2A (0.47) | ALDH1A1BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0756602-B1 | CCK OR GASTRIN MODULATING 5-HETEROCYCLIC-1,5-BENZODIAZEPINES | GLAXO WELLCOME INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0756602-A1 | CCK OR GASTRIN MODULATING 5-HETEROCYCLIC-1,5-BENZODIAZEPINES | GLAXO WELLCOME INC. (US) | 1997-02-05 | — | — | EP | disclosed |
| EP-0755384-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028419-A1 | CCK OR GASTRIN MODULATING 5-HETEROCYCLIC-1,5-BENZODIAZEPINES | GLAXO WELLCOME INC. (US) | 1995-10-26 | — | — | WO | disclosed |
| WO-1995028391-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1995-10-26 | — | — | WO | disclosed |