Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 7/20 | 0.40 |
| ▸ | BRD2 | P25440 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8405015 | 0.77 | CCKAR (0.48) | BRD4BRD2ALDH1A1 | |
| SCHEMBL8083341 | 0.68 | OPRM1 (0.49) | KMT2AMEN1MAPTALDH1A1OPRM1 | |
| SCHEMBL9491005 | 0.68 | ALDH1A1 (0.73) | KMT2AMEN1MAPTBRD4BRD2 | |
| SCHEMBL11551265 | 0.66 | BRPF1 (0.59) | KMT2AMEN1MAPTBRD4ALDH1A1 | |
| SCHEMBL1239192 | 0.65 | PDE3B (0.56) | KMT2AMEN1MAPTRAB9AALDH1A1 | |
| SCHEMBL11553211 | 0.65 | PDE3B (0.52) | KMT2AMEN1MAPTRAB9ABRD4 | |
| SCHEMBL1239067 | 0.62 | KMT2A (0.53) | KMT2AMEN1MAPTALDH1A1OPRM1 | |
| SCHEMBL3521937 | 0.62 | PDE3B (0.52) | KMT2AMEN1MAPTRAB9AALDH1A1 | |
| SCHEMBL8313816 | 0.62 | MAPT (0.43) | KMT2AMEN1MAPTALDH1A1OPRM1 | |
| SCHEMBL30094448 | 0.61 | PDE3B (0.68) | KMT2AMEN1MAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0756602-B1 | CCK OR GASTRIN MODULATING 5-HETEROCYCLIC-1,5-BENZODIAZEPINES | GLAXO WELLCOME INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0756602-A1 | CCK OR GASTRIN MODULATING 5-HETEROCYCLIC-1,5-BENZODIAZEPINES | GLAXO WELLCOME INC. (US) | 1997-02-05 | — | — | EP | disclosed |
| WO-1995028419-A1 | CCK OR GASTRIN MODULATING 5-HETEROCYCLIC-1,5-BENZODIAZEPINES | GLAXO WELLCOME INC. (US) | 1995-10-26 | — | — | WO | disclosed |