Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8761484 | 1.00 | HTR1A (0.53) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL8655841 | 0.86 | HTR1A (0.52) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL3596195 | 0.85 | CHRM1 (0.55) | CHRM1EPHX2HPGDKDM4EMAPT | |
| SCHEMBL9910968 | 0.84 | KCNQ2 (0.56) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL1589765 | 0.83 | HTR1A (0.53) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL12702338 | 0.83 | HTR1A (0.47) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL8405468 | 0.82 | HPGD (0.52) | HTR1AHTR1DHTR2BCHRM1HPGD | |
| SCHEMBL10575998 | 0.82 | HTR1A (0.52) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL8761469 | 0.82 | EPHX2 (0.52) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL7351452 | 0.81 | CHRM1 (0.58) | CHRM1EPHX2HPGDGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664799-B1 | AMIDE DERIVATIVES | WYETH JOHN & BROTHER LTD (GB) | 1999-07-14 | — | — | EP | disclosed |
| US-5637701-A | Process for preparing optically active amide derivatives | JOHN WYETH & BROTHER, LIMITED (GB) | 1997-06-10 | — | — | US | disclosed |
| EP-0664799-A1 | AMIDE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994008983-A1 | AMIDE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1994-04-28 | — | — | WO | disclosed |