Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995915 | 0.86 | DPP7 (0.49) | HPGDMAPTKMT2AGAADPP7 | |
| SCHEMBL8405067 | 0.86 | HTR1A (0.53) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL8761484 | 0.86 | HTR1A (0.53) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL9910968 | 0.83 | KCNQ2 (0.56) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL1589765 | 0.82 | HTR1A (0.53) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL8405468 | 0.81 | HPGD (0.52) | HTR1AHTR1DHTR2BCHRM1HPGD | |
| SCHEMBL10575998 | 0.81 | HTR1A (0.52) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL8761469 | 0.81 | EPHX2 (0.52) | HTR1AHTR1DHTR2BCHRM1EPHX2 | |
| SCHEMBL3596195 | 0.80 | CHRM1 (0.55) | CHRM1EPHX2HPGDKDM4EMAPT | |
| SCHEMBL8995919 | 0.80 | NPC1 (0.49) | HTR1AHTR1DHTR2BKMT2ADPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0678090-B1 | PIPERAZINE DERIVATIVES | WYETH JOHN & BROTHER LTD (GB) | 1998-10-14 | — | — | EP | disclosed |
| EP-0793663-A1 | (THIOPHEN-2-YL)-PIPERIDIN OR TETRAHYDROPYRIDIN CARBOXAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-10 | — | — | EP | disclosed |
| EP-0687257-B1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1997-06-18 | — | — | EP | disclosed |
| US-5627177-A | Piperazine derivatives | JOHN WYETH & BROTHER, LTD. (GB) | 1997-05-06 | — | — | US | disclosed |
| US-5610295-A | 4-amino-2-(hetero)aryl-butanamides useful as 5-HT1A -antagonists | JOHN WYETH & BROTHER, LTD. (GB) | 1997-03-11 | — | — | US | disclosed |
| US-5541179-A | Tropon-2-one piperazine carboxamides as serotonergic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |
| US-5527794-A | RELIEVING SYMPTOMS OF ANXIETY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-06-18 | — | — | US | disclosed |
| US-5525600-A | COMPOUND USEFUL AS ANTIPSYCHOTIC, ANTIDEPRESSANT AND ANXIBLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-06-11 | — | — | US | disclosed |
| WO-1996016961-A1 | (THIOPHEN-2-YL)-PIPERIDIN OR TETRAHYDROPYRIDIN CARBOXAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-06-06 | — | — | WO | disclosed |
| WO-1996012721-A1 | INDOLE DERIVATIVES USEFUL AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-02 | — | — | WO | disclosed |
| EP-0687257-A1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1995-12-20 | — | — | EP | disclosed |
| US-5466688-A | Antidepressants, anxiolytic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0678090-A1 | PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1995-10-25 | — | — | EP | disclosed |
| WO-1994020481-A1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |
| WO-1994015919-A1 | PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1994-07-21 | — | — | WO | disclosed |