⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4855767 | 0.85 | — | — | |
| SCHEMBL4650512 | 0.83 | CES2 (0.47) | — | |
| SCHEMBL4762004 | 0.81 | CES2 (0.50) | — | |
| SCHEMBL18525732 | 0.81 | CES2 (0.50) | — | |
| SCHEMBL9344941 | 0.81 | TP53 (0.38) | — | |
| SCHEMBL1756689 | 0.79 | — | — | |
| SCHEMBL19978698 | 0.79 | — | — | |
| SCHEMBL456288 | 0.79 | — | — | |
| SCHEMBL27797987 | 0.79 | — | — | |
| SCHEMBL14907190 | 0.78 | CRBN (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143408-B2 | N-(8-heteroaryltetrahydronaphtalene-2yl) or N-(5-heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | claimed |
| US-20100137322-A1 | NOVEL N-(8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N-(5-HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2010-06-03 | — | — | US | claimed |
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | claimed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| US-20180072721-A1 | NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5-DISUBSTITUTED-3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2018-03-15 | — | — | US | disclosed |
| US-9815831-B2 | 3,5-disubstituted-3H-imidazo[4,5-B]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo[4,5-B] pyridine compounds as modulators of c-Met protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2017-11-14 | — | — | US | disclosed |
| US-20150057309-A1 | NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN, ETC | RHIZEN PHARMACEUTICALS AG (CH) | 2015-02-26 | — | — | US | disclosed |
| US-20120238579-A1 | New Compounds 806 | BESIDKI YEVGENI (SE) | 2012-09-20 | — | — | US | disclosed |
| CN-101125714-B | Fluorescent polyether scale inhibitor and preparation method thereof | UNIV SOUTHEAST | 2012-05-23 | — | — | CN | disclosed |
| US-8143408-B2 | N-(8-heteroaryltetrahydronaphtalene-2yl) or N-(5-heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |
| CN-101003410-B | Agent of anti dirt of allylloxy polyether, and preparation method | UNIV SOUTHEAST | 2010-12-08 | — | — | CN | disclosed |
| US-20100137322-A1 | NOVEL N-(8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N-(5-HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2010-06-03 | — | — | US | disclosed |
| CN-101125714-A | Fluorescence polyether antisludging agent and preparation method | UNIV SOUTHEAST (CN) | 2008-02-20 | — | — | CN | disclosed |
| CN-101003410-A | Agent of anti dirt of allylloxy polyether, and preparation method | UNIV DONGNAN (CN) | 2007-07-25 | — | — | CN | disclosed |
| CN-1188404-C | Cyclic compound | FUJISAWA PHARMACEUTICAL CO (JP) | 2005-02-09 | — | — | CN | disclosed |
| CN-1425010-A | Cyclic compound | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-06-18 | — | — | CN | disclosed |
| EP-0818439-B1 | Imide derivatives | NISSHIN FLOUR MILLING CO (JP) | 1999-10-13 | — | — | EP | disclosed |
| US-5847123-A | Imide derivatives for inhibiting the production of interleukin-1β and the production of tumor necrosis factor α | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0818439-A2 | Imide derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-01-14 | — | — | EP | disclosed |
| EP-0103895-A2 | Novel hydroxylamine derivatives, production and use thereof | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1984-03-28 | — | — | EP | disclosed |