Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | HTR2C | P28335 | 7/20 | 0.67 |
| ▸ | HTR2B | P41595 | 7/20 | 0.67 |
| ▸ | HTR2A | P28223 | 6/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847453 | 0.94 | MAOA (0.77) | MAOATSHRHTR2CHTR2BHTR2A | |
| Salsolidine SCHEMBL1819825 | 0.87 | MAOA (1.00) | MAOATSHRHSD17B10CYP2D6ALDH1A1 | |
| Salsolidine SCHEMBL4250569 | 0.87 | MAOA (1.00) | MAOATSHRHSD17B10CYP2D6ALDH1A1 | |
| Salsolidine SCHEMBL34461883 | 0.87 | MAOA (1.00) | MAOATSHRHSD17B10CYP2D6ALDH1A1 | |
| Salsolidine SCHEMBL177753 | 0.87 | MAOA (1.00) | MAOATSHRHSD17B10CYP2D6ALDH1A1 | |
| Salsolidine SCHEMBL7838872 | 0.85 | MAOA (0.97) | MAOATSHRHSD17B10CYP2D6ALDH1A1 | |
| Salsolidine SCHEMBL5242077 | 0.85 | MAOA (1.00) | MAOATSHRHSD17B10CYP2D6ALDH1A1 | |
| SCHEMBL1009124 | 0.83 | MAOA (0.62) | MAOATSHRHTR2CHTR2BHTR2A | |
| SCHEMBL1094326 | 0.80 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL1094962 | 0.80 | HTR2C (1.00) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981521-A | USEFUL FOR TREATING VARIOUS HORMONE DEPENDENT DISEASES, INCLUDING PROSTATE CANCER, ENDOMETRIOSIS, UTERINE FIBROIDS, PRECOCIOUS PUBERTY, BENIGN PROSTATE HYPERTROPY AND IN VITRO FERTILIZATION | ABBOTT LABORATORIES (US) | 1999-11-09 | — | — | US | disclosed |