Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30508470 | 1.00 | SMN1; SMN2 (0.56) | SMN1; SMN2TDP1HRH3CXCR4ALDH1A1 | |
| SCHEMBL15260364 | 0.98 | SMN1; SMN2 (0.53) | SMN1; SMN2TDP1HRH3CXCR4ALDH1A1 | |
| SCHEMBL2933524 | 0.83 | MC4R (0.50) | TDP1ALDH1A1KDM4EPRMT6NPC1 | |
| SCHEMBL5255187 | 0.83 | HTT (0.51) | SMN1; SMN2HRH3CXCR4ALDH1A1HTT | |
| SCHEMBL5253497 | 0.83 | ALDH1A1 (0.49) | SMN1; SMN2TDP1CXCR4ALDH1A1KDM4E | |
| SCHEMBL30786089 | 0.81 | HRH3 (0.59) | TDP1HRH3CYP1A2L3MBTL1 | |
| SCHEMBL15260143 | 0.79 | CNR2 (0.44) | SMN1; SMN2TDP1CXCR4ALDH1A1CYP1A2 | |
| SCHEMBL31270902 | 0.79 | PIM1 (0.41) | CXCR4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7606866 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2TDP1HRH3CXCR4ALDH1A1 | |
| SCHEMBL2236348 | 0.79 | HRH3 (0.52) | SMN1; SMN2TDP1HRH3CXCR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478144-A | Preparation method of high-purity lafutidine | 内蒙古京科医药科技有限公司 | 2023-07-25 | — | — | CN | claimed |
| CN-102964295-A | Preparation method of 2-substituted-4-(piperidylmethyl)pyridine | Shouguang fukang pharmaceutical co ltd | 2013-03-13 | — | — | CN | disclosed |
| US-8143246-B2 | 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives | MSD OSS B.V. (NL) | 2012-03-27 | — | — | US | disclosed |
| CN-102304082-A | Synthesis method of 2-chloro-4-(piperidylmethyl)pyridine | UNIV CHANGZHOU | 2012-01-04 | — | — | CN | disclosed |
| EP-2373639-A1 | 1-(4-(PYRIDIN-2-YL)BENZYL)IMIDAZOLIDINE-2,4-DIONE DERIVATIVES | N.V. Organon (NL) | 2011-10-12 | — | — | EP | disclosed |
| US-7846930-B2 | Diaryl-substituted tetrahydroisoquinolines as histamine H3 receptor and serotonin transporter modulators | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-07 | — | — | US | disclosed |
| US-20100144724-A1 | 1-(4-(PYRIDIN-2-YL)BENZYL)IMIDAZOLIDINE-2,4-DIONE DERIVATIVES | N.V.ORGANON | 2010-06-10 | — | — | US | disclosed |
| WO-2010063666-A1 | 1-(4-(PYRIDIN-2-YL)BENZYL)IMIDAZOLIDINE-2,4-DIONE DERIVATIVES | N.V. ORGANON (NL) | 2010-06-10 | — | — | WO | disclosed |
| US-20080318952-A1 | DIARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-25 | — | — | US | disclosed |
| WO-2008144305-A1 | DIARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-11-27 | — | — | WO | disclosed |
| EP-0282077-B1 | Pyridyloxy derivatives | FUJIREBIO KK (JP) | 1993-11-10 | — | — | EP | disclosed |
| EP-0177016-B1 | PYRIDYLOXY DERIVATIVES | Ikeda Mohando Co., Ltd. (JP) | 1993-06-23 | — | — | EP | disclosed |
| US-4977267-A | ANTISECRETORY AGENT | FUJIREBIO KABUSHIKI KAISHA (JP) | 1990-12-11 | — | — | US | disclosed |
| US-4912101-A | Containing a secondary amide, suflur group and a furan ring | FUJIREBIO KABUSHIKI KAISHA (JP) | 1990-03-27 | — | — | US | disclosed |
| US-4808589-A | Pyrimidone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-28 | — | — | US | disclosed |
| EP-0282077-A2 | Pyridyloxy derivatives | FUJIREBIO KABUSHIKI KAISHA (JP) | 1988-09-14 | — | — | EP | disclosed |
| US-4710498-A | ANTIULCER AGENTS | IKEDA MOHANDO CO., LTD. (JP) | 1987-12-01 | — | — | US | disclosed |
| EP-0177016-A2 | Pyridyloxy derivatives | Ikeda Mohando Co., Ltd. (JP) | 1986-04-09 | — | — | EP | disclosed |
| EP-0087274-A2 | Pyrimidone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-08-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318952-A1 | DIARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS | HRH3, HRH4, HRH1 | SMN1; SMN2 4305/4885TDP1 2904/4885HRH3 1/4885 |
| US-20100144724-A1 | 1-(4-(PYRIDIN-2-YL)BENZYL)IMIDAZOLIDINE-2,4-DIONE DERIVATIVES | OPRD1, CNR1, CNR2 | SMN1; SMN2 87/4885TDP1 3340/4885HRH3 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.