Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 3/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8226920 | 0.85 | KMT2A (0.52) | KMT2AMEN1MAPTNPSR1ALDH1A1 | |
| SCHEMBL917365 | 0.81 | GALR3 (0.56) | KMT2AMEN1MAPTNPSR1ALDH1A1 | |
| SCHEMBL917367 | 0.81 | GALR3 (0.56) | KMT2AMEN1MAPTNPSR1ALDH1A1 | |
| SCHEMBL12942336 | 0.80 | KMT2A (0.52) | KMT2AMEN1MAPTNPSR1ALDH1A1 | |
| SCHEMBL8410768 | 0.78 | KMT2A (0.50) | KMT2AMEN1MAPTNPSR1ALDH1A1 | |
| SCHEMBL8404173 | 0.77 | KMT2A (0.50) | KMT2AMEN1MAPTNPSR1ALDH1A1 | |
| SCHEMBL8404175 | 0.75 | MAPT (0.47) | KMT2AMEN1MAPTNPSR1ALDH1A1 | |
| SCHEMBL8405541 | 0.74 | KMT2A (0.44) | KMT2AMEN1MAPTNPSR1ALDH1A1 | |
| SCHEMBL12938088 | 0.73 | ALDH1A1 (0.65) | KMT2AMEN1MAPTNPSR1ALDH1A1 | |
| SCHEMBL13086556 | 0.70 | MAPT (0.64) | KMT2AMEN1MAPTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030078271-A1 | Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078271-A1 | Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods | GALR3, GALR2, GALR1 | KMT2A 4393/4885MEN1 4213/4885MAPT 3040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.