Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | CES2 | O00748 | 1/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.61 |
| ▸ | CES1 | P23141 | 1/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GALR3 | O60755 | 1/20 | 0.52 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | SNCA | P37840 | 2/20 | 0.46 |
| ▸ | PDE6D | O43924 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12938088 | 0.86 | ALDH1A1 (0.65) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL13628014 | 0.83 | ALDH1A1 (0.61) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL12805765 | 0.83 | ALDH1A1 (0.61) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL6322884 | 0.83 | ALDH1A1 (0.61) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL12805764 | 0.83 | ALDH1A1 (0.61) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL6322887 | 0.83 | ALDH1A1 (0.61) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL6323819 | 0.82 | MAPT (0.72) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL6323811 | 0.82 | MAPT (0.72) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL917246 | 0.79 | GALR3 (0.58) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL917249 | 0.79 | GALR3 (0.58) | MAPTKMT2AMEN1NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2241316-A1 | Indolone compounds useful to treat cognitive impairment | Helicon Therapeutics, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| US-20100179187-A1 | INDOLONE COMPOUNDS USEFUL TO TREAT COGNITIVE IMPAIRMENT | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179187-A1 | INDOLONE COMPOUNDS USEFUL TO TREAT COGNITIVE IMPAIRMENT | CHAT, AANAT, TPH2 | MAPT 100/4885KMT2A 1706/4885MEN1 3410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.