Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 5/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | GFER | P55789 | 1/20 | 0.68 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.68 |
| ▸ | BRAF | P15056 | 2/20 | 0.67 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.61 |
| ▸ | HTRA2 | O43464 | 2/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 3/20 | 0.58 |
| ▸ | MMP2 | P08253 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | RECQL | P46063 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8406198 | 0.84 | HTRA2 (0.62) | POLBMEN1KMT2AGFERCTDSP1 | |
| SCHEMBL3892654 | 0.83 | APEX1 (0.71) | POLBMEN1KMT2AGFERCTDSP1 | |
| SCHEMBL3892650 | 0.83 | APEX1 (0.71) | POLBMEN1KMT2AGFERCTDSP1 | |
| SCHEMBL29665060 | 0.81 | LCK (0.73) | POLBMEN1KMT2AGFERCTDSP1 | |
| SCHEMBL31358664 | 0.79 | PIM1 (0.72) | POLBMEN1KMT2AGFERCTDSP1 | |
| SCHEMBL13587005 | 0.79 | GSK3A (0.81) | POLBMEN1KMT2AGFERCTDSP1 | |
| SCHEMBL6795412 | 0.79 | APEX1 (0.70) | POLBMEN1KMT2ABRAFTDP1 | |
| SCHEMBL19652472 | 0.77 | GSK3A (0.79) | POLBMEN1KMT2ATDP1MAPT | |
| SCHEMBL10091431 | 0.77 | PIM1 (0.62) | POLBMEN1KMT2AGFERCTDSP1 | |
| SCHEMBL14426531 | 0.76 | PTPN1 (0.75) | POLBMEN1KMT2AGFERCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242122-B2 | Method and compounds for inhibition of cell death | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-08-14 | — | — | US | disclosed |
| US-8242122-B2 | Method and compounds for inhibition of cell death | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-08-14 | — | — | US | disclosed |
| US-7713981-B2 | Method and compounds for inhibition of cell death | UNIVERSITY OF CENTRAL FLORIDA (US) | 2010-05-11 | — | — | US | disclosed |
| US-20040171629-A1 | Method and compounds for inhibition of cell death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-09-02 | — | — | US | disclosed |