Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNLIP | P16233 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2701312 | 0.89 | PNLIP (0.63) | PNLIPLMNAMEN1KMT2ATP53 | |
| SCHEMBL12368148 | 0.86 | NPC1 (0.71) | MEN1KMT2AHTTNPC1RAB9A | |
| SCHEMBL8406630 | 0.85 | P2RX1 (0.75) | PNLIPLMNAMEN1KMT2ATP53 | |
| SCHEMBL15361447 | 0.84 | PTGS1 (0.68) | TP53HTTKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL27940176 | 0.84 | EPHX2 (0.58) | TP53HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1496356 | 0.84 | TRPV1 (0.59) | TP53HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12225782 | 0.84 | NPC1 (0.69) | LMNAMEN1KMT2AHTTNPC1 | |
| SCHEMBL29168845 | 0.84 | TDP1 (0.62) | MEN1KMT2ATP53HTTNPC1 | |
| SCHEMBL1499598 | 0.84 | SMN1; SMN2 (0.68) | MEN1KMT2AHTTKDM4ENPC1 | |
| SCHEMBL18327174 | 0.82 | LMNA (0.89) | PNLIPLMNAMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150210717-A1 | SPECIFIC INHIBITORS OF PROTEIN P21 AS THERAPEUTIC AGENTS | LEIBNIZ-INSTITUT FÜR ALTERSFORSCHUNG (DE) | 2015-07-30 | — | — | US | disclosed |
| CN-104334529-A | Compounds and compositions for inhibiting the activity of ABL1, ABL2, and BCR-ABL1 | NOVARTIS AG | 2015-02-04 | — | — | CN | disclosed |
| WO-2014041125-A1 | SPECIFIC INHIBITORS OF PROTEIN P21 AS THERAPEUTIC AGENTS | BADEN-WÜRTTEMBERG STIFTUNG GMBH (DE) | 2014-03-20 | — | — | WO | disclosed |
| US-5905090-A | IMMUNOSUPPRESSANTS AND/OR ANTIINFLAMMATORIES | ITALFARMACO S.P.A. (IT) | 1999-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210717-A1 | SPECIFIC INHIBITORS OF PROTEIN P21 AS THERAPEUTIC AGENTS | CDKN1A, ING2, BCCIP | PNLIP 1298/4885LMNA 2489/4885MEN1 2917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.