Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 16/20 | 0.54 |
| ▸ | PGR | P06401 | 16/20 | 0.54 |
| ▸ | AR | P10275 | 10/20 | 0.54 |
| ▸ | ESR1 | P03372 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.48 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622523 | 0.91 | NR3C1 (0.59) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL8408961 | 0.80 | NR3C1 (0.57) | NR3C1PGRARCYP2C8 | |
| SCHEMBL8619892 | 0.79 | NR3C1 (0.46) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL8407122 | 0.79 | PGR (0.40) | NR3C1PGRARCYP3A4TDP1 | |
| SCHEMBL8620743 | 0.79 | NR3C1 (0.45) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL8407402 | 0.77 | NR3C1 (0.54) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL8408969 | 0.77 | NR3C1 (0.48) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL8407360 | 0.77 | NR3C1 (0.47) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL8407253 | 0.77 | NR3C1 (0.49) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL8620050 | 0.77 | NR3C1 (0.47) | NR3C1PGRARESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0565553-B1 | 6,7-MODIFIED 11$g(b)-ARYL-4-ESTRENES | SCHERING AG (DE) | 1999-07-21 | — | — | EP | claimed |
| EP-0565553-B1 | 6,7-MODIFIED 11$g(b)-ARYL-4-ESTRENES | SCHERING AG (DE) | 1999-07-21 | — | — | EP | disclosed |
| US-5843931-A | 6,7-modified 11β-aryl-4-oestrenes | SHERING AKTIENGESELLSCHAFT (DE) | 1998-12-01 | — | — | US | disclosed |