SCHEMBL8407380

SCHEMBL8407380

CC(C)C(=O)N(C)c1ccc([N+](=O)[O-])c(C(F)(F)F)c1Br

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 5/20 0.40
ALDH1A1 P00352 2/20 0.40
MAPK1 P28482 2/20 0.40
CYP3A4 P08684 2/20 0.40
CES2 O00748 1/20 0.40
ABCB11 O95342 1/20 0.40
LMNA P02545 1/20 0.40
CYP1A2 P05177 1/20 0.40
GLA P06280 1/20 0.40
ADORA3 P0DMS8 1/20 0.40
CHRM1 P11229 1/20 0.40
CYP2C9 P11712 1/20 0.40
ALOX15 P16050 1/20 0.40
TSHR P16473 1/20 0.40
TBXA2R P21731 1/20 0.40
AADAC P22760 1/20 0.40
CYP2C19 P33261 1/20 0.40
ADRA1A P35348 1/20 0.40
HTT P42858 1/20 0.40
HTR6 P50406 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8407241 0.87 AR (0.49) ARALDH1A1MAPK1CYP3A4CES2
SCHEMBL8410305 0.84 MLYCD (0.40) ARALDH1A1MAPK1CYP3A4CES2
SCHEMBL8410215 0.83 AR (0.39) ARALDH1A1MAPK1CYP3A4CES2
SCHEMBL8407531 0.82 MLYCD (0.42) ARALDH1A1MAPK1CYP3A4CES2
SCHEMBL8409226 0.81 MLYCD (0.44) ARALDH1A1MAPK1CYP3A4CES2
SCHEMBL11877918 0.77 KMT2A (0.48) ARALDH1A1MAPK1CYP3A4CES2
SCHEMBL11874578 0.77 MAPT (0.50) ARALDH1A1MAPK1CYP3A4CES2
SCHEMBL11873015 0.74 ALDH1A1 (0.46) ARALDH1A1MAPK1CYP3A4CES2
SCHEMBL8409003 0.73 AR (0.55) ARALDH1A1MAPK1CYP3A4CES2
SCHEMBL11510593 0.72 AR (0.56) ARALDH1A1MAPK1CYP3A4CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994362-A ADMINISTERING FINASTERIDE AND CASODEX MERCK & CO., INC. (US) 1999-11-30 US disclosed
EP-0514056-A2 Use of estrogens or antiandrogens for reversal of male sexual phenotype in poultry MERCK & CO. INC. (US) 1992-11-19 EP disclosed
WO-1992016233-A1 PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN MERCK & CO., INC. (US) 1992-10-01 WO disclosed