Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8406460 | 0.80 | DRD4 (0.48) | PARP1TNK2TNK1PANK3HTR7 | |
| SCHEMBL6844235 | 0.76 | HTR7 (0.60) | HTR7OPRM1CYP2C9 | |
| SCHEMBL6924625 | 0.70 | HRH3 (0.65) | HRH3PARP1TNK2TNK1PANK3 | |
| SCHEMBL9854895 | 0.69 | HTR7 (0.38) | POLBHTR7OPRM1LRRK2KDM4E | |
| SCHEMBL8407627 | 0.67 | HTR7 (0.41) | HRH3PARP1TNK2TNK1PANK3 | |
| SCHEMBL10268958 | 0.66 | HRH4 (0.55) | HRH3PANK3HTR7CNR2LRRK2 | |
| SCHEMBL11283504 | 0.65 | DRD2 (0.44) | HTR7 | |
| SCHEMBL10986480 | 0.65 | DRD2 (0.45) | POLBHTR7OPRM1CYP2C9ABL1 | |
| SCHEMBL17843264 | 0.65 | PANK3 (0.51) | HRH3PARP1TNK2TNK1PANK3 | |
| SCHEMBL10423416 | 0.65 | POLB (0.42) | POLBOPRM1CYP2C9CHRM4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883094-A | Benzimidazolone derivatives with central dopaminergic activity | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |