Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 3/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.47 |
| ▸ | PPIA | P62937 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8431920 | 0.89 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2BRD4MRGPRX4 | |
| SCHEMBL2894833 | 0.87 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2BRD4MRGPRX4 | |
| SCHEMBL2892753 | 0.82 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2BRD4MRGPRX4 | |
| Hydrochloric Acid SCHEMBL28557881 | 0.78 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2BRD4MRGPRX4 | |
| SCHEMBL8405081 | 0.77 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2BRD4MRGPRX4 | |
| SCHEMBL4825037 | 0.77 | NLRP3 (0.58) | RAB9ASMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL21862932 | 0.75 | NPC1 (0.45) | NPC1RAB9ABRD4MRGPRX4MEN1 | |
| SCHEMBL27724257 | 0.74 | NPC1 (0.53) | NPC1RAB9ABRD4MRGPRX4MEN1 | |
| SCHEMBL2897224 | 0.74 | MRGPRX4 (0.62) | NPC1MRGPRX4MEN1KMT2AKDM1A | |
| SCHEMBL27849246 | 0.74 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2BRD4MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624567-B1 | Derivatives of 3-fluorophenol, process for their preparation and their use | CLARIANT GMBH (DE) | 1999-12-08 | — | — | EP | disclosed |
| EP-0628536-B1 | Process for the preparation of aromatic amines | CLARIANT GMBH (DE) | 1999-07-14 | — | — | EP | disclosed |
| US-5410082-A | Process for preparing amines | CLARIANT GMBH (DE) | 1995-04-25 | — | — | US | disclosed |
| EP-0628536-A2 | Process for the preparation of amines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-14 | — | — | EP | disclosed |
| EP-0624567-A2 | Derivatives of 3-fluorophenol, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-17 | — | — | EP | disclosed |