SCHEMBL8408779

SCHEMBL8408779

CC(C)(O)Cc1cc(O)ccc1Br

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 4/20 0.36
TYR P14679 4/20 0.35
HSD17B10 Q99714 4/20 0.35
LMNA P02545 3/20 0.35
ALDH1A1 P00352 2/20 0.35
ALOX15 P16050 2/20 0.35
CYP2C9 P11712 2/20 0.35
NR1I2 O75469 1/20 0.35
MIF P14174 1/20 0.35
HTT P42858 1/20 0.35
NFE2L2 Q16236 1/20 0.35
ESR2 Q92731 3/20 0.33
HPGD P15428 3/20 0.32
HIF1A Q16665 3/20 0.32
CYP3A4 P08684 2/20 0.32
TSHR P16473 2/20 0.32
ALOX12 P18054 1/20 0.32
CASP1 P29466 1/20 0.32
RECQL P46063 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8408839 0.81 TYR (0.35) TYRHSD17B10LMNAALDH1A1ALOX15
SCHEMBL17429682 0.81 FFAR4 (0.36) ALDH1A1CYP2C9HPGDHIF1ATSHR
SCHEMBL17385951 0.77 IDO1 (0.41) HSD17B10HPGDSLC6A4
SCHEMBL1513563 0.75 HSD17B3 (0.42) ESR1TYRALOX15HTTESR2
SCHEMBL30388724 0.74 RIPK1 (0.45) HSD17B10LMNAALDH1A1TSHRSLC6A2
SCHEMBL2401345 0.74 RIPK1 (0.45) HSD17B10LMNAALDH1A1TSHRSLC6A2
SCHEMBL8753514 0.73 TYR (0.39) ESR1TYRALOX15ESR2ALOX12
SCHEMBL2527333 0.73 TYR (0.39) TYRALOX15ESR2BACE1EGFR
SCHEMBL869864 0.72 ALDH1A1 (0.50) HSD17B10LMNAALDH1A1ALOX15CYP2C9
SCHEMBL21241614 0.72 HSD17B3 (0.44) TYRHSD17B10ALDH1A1ALOX15CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5962469-A PREVENTION OF OXIDATION TISSUE DAMAGE BY FREE RADICALS HOECHST MARION ROUSSEL INC. (US) 1999-10-05 US disclosed
EP-0863878-A1 CYCLIC NITRONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM HOECHST MARION ROUSSEL, INC. (US) 1998-09-16 EP disclosed
WO-1997010218-A1 CYCLIC NITRONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM HOECHST MARION ROUSSEL, INC. (US) 1997-03-20 WO disclosed