Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | PLK1 | P53350 | 2/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | CTRC | Q99895 | 3/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | SNCA | P37840 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8292403 | 1.00 | PDGFRB (0.61) | PDGFRBKDRFGFR1SRCPLK4 | |
| SCHEMBL6405982 | 0.81 | DYRK1A (0.55) | PDGFRBKDRPLK4PLK1RET | |
| SCHEMBL6392297 | 0.81 | DYRK1A (0.55) | PDGFRBKDRPLK4PLK1RET | |
| SCHEMBL8300628 | 0.81 | CTRC (0.62) | PDGFRBKDRFGFR1SRCPLK4 | |
| SCHEMBL8411569 | 0.81 | CTRC (0.62) | PDGFRBKDRFGFR1SRCPLK4 | |
| SCHEMBL8291290 | 0.78 | CTRC (0.66) | PDGFRBKDRFGFR1SRCPLK4 | |
| SCHEMBL8431267 | 0.78 | CTRC (0.66) | PDGFRBKDRFGFR1SRCPLK4 | |
| SCHEMBL5469409 | 0.78 | KDR (0.73) | PDGFRBKDRPLK4PLK1RET | |
| SCHEMBL5474945 | 0.78 | MAPT (0.68) | PDGFRBKDRPLK4PLK1RET | |
| SCHEMBL5469417 | 0.78 | KDR (0.73) | PDGFRBKDRPLK4PLK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662473-B1 | 2-Oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN SPA (IT) | 1999-09-01 | — | — | EP | claimed |