Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRC | Q99895 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.56 |
| ▸ | PLK4 | O00444 | 3/20 | 0.56 |
| ▸ | PLK1 | P53350 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | IGF1R | P08069 | 2/20 | 0.55 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | DHFR | P00374 | 1/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300628 | 1.00 | CTRC (0.62) | CTRCRAF1PDGFRBPLK4PLK1 | |
| SCHEMBL8408974 | 0.81 | PDGFRB (0.61) | CTRCRAF1PDGFRBPLK4PLK1 | |
| SCHEMBL8292403 | 0.81 | PDGFRB (0.61) | CTRCRAF1PDGFRBPLK4PLK1 | |
| SCHEMBL8434574 | 0.81 | CTRC (0.69) | CTRCRAF1PDGFRBPLK4PLK1 | |
| SCHEMBL8296153 | 0.81 | CTRC (0.69) | CTRCRAF1PDGFRBPLK4PLK1 | |
| SCHEMBL8296380 | 0.81 | CTRC (0.72) | CTRCRAF1PDGFRBPLK4PLK1 | |
| SCHEMBL8411639 | 0.81 | CTRC (0.72) | CTRCRAF1PDGFRBPLK4PLK1 | |
| SCHEMBL8409427 | 0.79 | CTRC (0.74) | CTRCRAF1PDGFRBPLK4PLK1 | |
| SCHEMBL8296148 | 0.79 | CTRC (0.74) | CTRCRAF1PDGFRBPLK4PLK1 | |
| SCHEMBL8431267 | 0.79 | CTRC (0.66) | CTRCRAF1PDGFRBPLK4PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662473-B1 | 2-Oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN SPA (IT) | 1999-09-01 | — | — | EP | claimed |