Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 6/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.37 |
| ▸ | AR | P10275 | 4/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.34 |
| ▸ | EBP | Q15125 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8409403 | 0.89 | SRD5A2 (0.39) | SRD5A2PGRNR3C1ARCYP19A1 | |
| SCHEMBL8407060 | 0.83 | SRD5A2 (0.38) | SRD5A2CYP19A1CYP3A4 | |
| SCHEMBL6841930 | 0.83 | SRD5A2 (0.44) | SRD5A2CYP19A1CYP3A4 | |
| SCHEMBL9811534 | 0.80 | SRD5A2 (0.41) | SRD5A2CYP19A1CYP3A4 | |
| SCHEMBL23131219 | 0.80 | NR3C1 (0.41) | SRD5A2PGRNR3C1ARCYP19A1 | |
| SCHEMBL21539663 | 0.80 | NR3C1 (0.41) | SRD5A2PGRNR3C1ARCYP19A1 | |
| SCHEMBL21143398 | 0.80 | NR3C1 (0.41) | SRD5A2PGRNR3C1ARCYP19A1 | |
| SCHEMBL8623329 | 0.79 | NR3C1 (0.51) | PGRNR3C1ARSIGMAR1CYP3A4 | |
| SCHEMBL17591557 | 0.77 | SRD5A2 (0.63) | SRD5A2CYP19A1 | |
| SCHEMBL17831186 | 0.77 | SRD5A2 (0.63) | SRD5A2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0565553-B1 | 6,7-MODIFIED 11$g(b)-ARYL-4-ESTRENES | SCHERING AG (DE) | 1999-07-21 | — | — | EP | disclosed |
| US-5843931-A | 6,7-modified 11β-aryl-4-oestrenes | SHERING AKTIENGESELLSCHAFT (DE) | 1998-12-01 | — | — | US | disclosed |