Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410817 | 0.85 | MAP4K4 (0.41) | MAPK8MAPK10MAPK14MAP4K4EPHX2 | |
| SCHEMBL8409058 | 0.76 | ALOX5 (0.47) | MAPK8MAPK10MAPK14MAP4K4ALOX5 | |
| SCHEMBL8179368 | 0.74 | ALOX5 (0.60) | CNR2CNR1ALOX5TP53MAPT | |
| SCHEMBL332276 | 0.70 | MAP4K4 (0.56) | MAPK8MAPK10MAPK14MAP4K4HDAC3 | |
| SCHEMBL15587796 | 0.69 | NPSR1 (0.59) | MAPK8MAPK10MAPK14MAP4K4HDAC3 | |
| SCHEMBL19015883 | 0.69 | SMN1; SMN2 (0.50) | MAPK8MAPK10MAPK14MAP4K4F10 | |
| SCHEMBL28872344 | 0.66 | SMN1; SMN2 (0.56) | MAPK8MAPK10MAPK14MAP4K4F10 | |
| SCHEMBL8410878 | 0.66 | MAP4K4 (0.52) | MAPK8MAPK10MAPK14MAP4K4HDAC3 | |
| SCHEMBL6438927 | 0.65 | ALOX5 (0.57) | MAPK8MAPK10MAPK14MAP4K4SIRT2 | |
| SCHEMBL17896325 | 0.65 | MAP4K4 (0.48) | MAPK8MAPK10MAPK14MAP4K4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883106-A | 5-lipoxygenase inhibitors | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |