Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PIP5K1C | O60331 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438927 | 0.87 | ALOX5 (0.57) | ALOX5MAPK10MAPK14MAPK8MAP4K4 | |
| SCHEMBL8410817 | 0.86 | MAP4K4 (0.41) | MAPK10MAPK14MAPK8MAP4K4PIP5K1C | |
| SCHEMBL8409250 | 0.82 | ALOX5 (0.62) | ALOX5 | |
| Hydrochloric Acid SCHEMBL8411350 | 0.81 | ALOX5 (0.61) | ALOX5 | |
| SCHEMBL8409240 | 0.76 | MAPK8 (0.39) | ALOX5MAPK10MAPK14MAPK8MAP4K4 | |
| SCHEMBL8413218 | 0.74 | ALOX5 (0.53) | ALOX5 | |
| SCHEMBL8179150 | 0.74 | ALOX5 (0.77) | ALOX5ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3061917 | 0.73 | ALOX5 (0.76) | ALOX5ALDH1A1 | |
| SCHEMBL8412085 | 0.73 | ALOX5 (0.55) | ALOX5 | |
| SCHEMBL8411616 | 0.73 | ALOX5 (0.55) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883106-A | 5-lipoxygenase inhibitors | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |