Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 8/20 | 0.49 |
| ▸ | RXRA | P19793 | 8/20 | 0.49 |
| ▸ | RXRB | P28702 | 7/20 | 0.49 |
| ▸ | RXRG | P48443 | 6/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8409645 | 0.91 | MAPT (0.48) | RXRARXRBRXRGCYP2C9MRGPRX4 | |
| SCHEMBL8406653 | 0.89 | RXRA (0.61) | PTGER1RXRARXRBRXRGCYP2C9 | |
| SCHEMBL8797760 | 0.83 | RXRA (0.54) | PTGER1RXRARXRBRXRGCYP2C9 | |
| SCHEMBL8409338 | 0.81 | PTGER1 (0.53) | PTGER1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL8406725 | 0.80 | RXRA (0.70) | PTGER1RXRARXRBRXRGPTGER4 | |
| SCHEMBL8406663 | 0.78 | RXRA (0.38) | RXRARXRBRXRGMAPT | |
| SCHEMBL8409736 | 0.77 | MAPT (0.55) | CYP2C9MAPT | |
| SCHEMBL8406711 | 0.77 | CYP1A2 (0.37) | RXRARXRBRXRGMAPT | |
| SCHEMBL28295384 | 0.77 | RXRA (0.52) | PTGER1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL8406707 | 0.77 | SMN1; SMN2 (0.52) | PTGER1RXRARXRBRXRGCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778821-B1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LTD (GB) | 1999-10-20 | — | — | EP | disclosed |
| US-5965741-A | ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES | ZENECA LIMITED (GB) | 1999-10-12 | — | — | US | disclosed |
| EP-0778821-A1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LIMITED (GB) | 1997-06-18 | — | — | EP | disclosed |