Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.54 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8408009 | 0.88 | KCNA5 (0.56) | SLC6A7KCNA5USP2CYP2C9TSHR | |
| SCHEMBL15557487 | 0.84 | KCNA5 (0.53) | SLC6A7KCNA5USP2CYP2C9TSHR | |
| SCHEMBL8410628 | 0.81 | PTGER4 (0.54) | SLC6A7USP2CYP2C9TSHRCYP1A2 | |
| SCHEMBL8407569 | 0.81 | CCNK (0.51) | SLC6A7USP2CYP2C9TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL8714344 | 0.81 | KDM1A (0.54) | ALDH1A1DRD2MEN1KMT2ADRD3 | |
| SCHEMBL15557338 | 0.79 | KCNA5 (0.52) | SLC6A7KCNA5USP2CYP2C9TSHR | |
| SCHEMBL16627284 | 0.79 | KCNA5 (0.68) | KCNA5USP2CYP2C9TSHRCYP1A2 | |
| SCHEMBL9171577 | 0.78 | POLB (0.59) | KCNA5SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL19634410 | 0.77 | DRD2 (0.50) | HRH3ALDH1A1DRD2MEN1KMT2A | |
| SCHEMBL8560134 | 0.77 | KDM1A (0.49) | NOS1NOS2ALDH1A1CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |