Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.52 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13204584 | 0.85 | NISCH (0.54) | NISCHPRMT1 | |
| SCHEMBL9241934 | 0.84 | CHEK2 (0.66) | CHEK2 | |
| SCHEMBL8141749 | 0.79 | NISCH (1.00) | NISCHMAOAMAOB | |
| SCHEMBL548343 | 0.79 | NISCH (0.50) | NISCHMAOBPRMT1 | |
| SCHEMBL549218 | 0.79 | TOP2A (0.56) | NISCHPRMT1 | |
| SCHEMBL8677423 | 0.79 | NISCH (0.50) | NISCHMAOBPRMT1 | |
| SCHEMBL548359 | 0.79 | NISCH (0.52) | NISCHPRMT1 | |
| SCHEMBL8477890 | 0.79 | NPC1 (0.58) | NISCHPRMT1 | |
| SCHEMBL14599548 | 0.78 | PRMT1 (0.49) | NISCHPRMT1 | |
| SCHEMBL14599545 | 0.77 | NISCH (0.48) | NISCHPRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942532-A | INHIBITORS OF HISTIDINE PROTEIN KINASE; BACTERIA RESISTANT TO OTHER ANTIBIOTICS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1999-08-24 | — | — | US | disclosed |
| WO-1999011627-A1 | 2-SUBSTITUTED PHENYL-BENZIMIDAZOLE ANTIBACTERIAL AGENTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-03-11 | — | — | WO | disclosed |