Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 8/20 | 0.54 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14599548 | 0.89 | PRMT1 (0.49) | NISCHPRMT1 | |
| SCHEMBL20184770 | 0.89 | PRMT1 (0.53) | NISCHPRMT1LMNARECQL | |
| SCHEMBL14599545 | 0.88 | NISCH (0.48) | NISCHPRMT1 | |
| SCHEMBL548359 | 0.87 | NISCH (0.52) | NISCHPRMT1 | |
| SCHEMBL20982698 | 0.85 | PRMT1 (0.56) | NISCHPRMT1RECQL | |
| SCHEMBL8409651 | 0.85 | NISCH (0.64) | NISCHPRMT1 | |
| SCHEMBL548343 | 0.85 | NISCH (0.50) | NISCHPRMT1 | |
| SCHEMBL549218 | 0.85 | TOP2A (0.56) | NISCHPRMT1TOP2ATOP2B | |
| SCHEMBL8677423 | 0.85 | NISCH (0.50) | NISCHPRMT1 | |
| SCHEMBL23775778 | 0.83 | PRMT1 (0.44) | NISCHPRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781183-B2 | Inhibition of anthrax lethal factor protease | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781183-B2 | Inhibition of anthrax lethal factor protease | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2010-08-24 | — | — | US | disclosed |