SCHEMBL8409696

SCHEMBL8409696

O=[C]c1cc2cc([N+](=O)[O-])ccc2[nH]1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.55
MAPT P10636 4/20 0.49
NOS1 P29475 2/20 0.49
POLB P06746 1/20 0.49
MAOB P27338 1/20 0.49
GRIA1 P42261 1/20 0.49
GRIA2 P42262 1/20 0.49
GRIA3 P42263 1/20 0.49
GRIA4 P48058 1/20 0.49
HRH4 Q9H3N8 1/20 0.45
CA12 O43570 2/20 0.44
CA9 Q16790 2/20 0.44
CRHBP P24387 1/20 0.44
CRHR2 Q13324 1/20 0.44
ALDH1A1 P00352 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
PARP1 P09874 2/20 0.42
CTSV O60911 1/20 0.42
CTSL P07711 1/20 0.42
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1673078 0.79 CYP19A1 (0.76) CYP19A1MAPTNOS1POLBMAOB
SCHEMBL28389620 0.77 CYP19A1 (0.59) CYP19A1MAPTNOS1POLBMAOB
SCHEMBL27277838 0.76 CYP19A1 (0.58) CYP19A1MAPTNOS1POLBMAOB
SCHEMBL10172985 0.76 CYP19A1 (0.58) CYP19A1MAPTNOS1POLBMAOB
SCHEMBL30917347 0.76 CYP19A1 (0.60) CYP19A1MAPTNOS1POLBMAOB
SCHEMBL317330 0.76 CYP19A1 (0.60) CYP19A1MAPTNOS1POLBMAOB
SCHEMBL12778277 0.76 CYP19A1 (0.58) CYP19A1MAPTNOS1POLBMAOB
SCHEMBL397992 0.73 MAPT (0.49) MAPTNOS1POLBGRIA1GRIA2
SCHEMBL5828547 0.73 CYP19A1 (0.55) CYP19A1MAPTNOS1POLBMAOB
SCHEMBL27885276 0.73 HRH4 (0.61) CYP19A1MAPTNOS1POLBMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5866589-A Alkyl substituted piperadinyl and piperazinyl anti-AIDS compounds PHARMACIA & UPJOHN COMPANY (US) 1999-02-02 US disclosed
EP-0797576-A1 ALKYL SUBSTITUTED PIPERADINYL AND PIPERAZINYL ANTI-AIDS COMPOUNDS PHARMACIA & UPJOHN COMPANY (US) 1997-10-01 EP disclosed
WO-1996018628-A1 ALKYL SUBSTITUTED PIPERADINYL AND PIPERAZINYL ANTI-AIDS COMPOUNDS PHARMACIA & UPJOHN COMPANY (US) 1996-06-20 WO disclosed