Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 15/20 | 0.61 |
| ▸ | BCHE | P06276 | 10/20 | 0.57 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10370396 | 0.89 | ACHE (0.50) | ACHEBCHEPRMT6HRH2 | |
| SCHEMBL2458150 | 0.88 | ACHE (0.74) | ACHEBCHEPRMT6CYP2A6CYP2C19 | |
| SCHEMBL9838312 | 0.80 | — | — | |
| SCHEMBL12655116 | 0.79 | ACHE (0.63) | ACHEBCHEPRMT6CYP2A6CYP2C19 | |
| SCHEMBL8610492 | 0.77 | ACHE (0.61) | ACHEBCHEPRMT6CYP2A6CYP2C19 | |
| SCHEMBL8011063 | 0.77 | ACHE (0.61) | ACHEBCHEPRMT6CYP2A6CYP2C19 | |
| SCHEMBL8007208 | 0.77 | ACHE (0.55) | ACHEBCHEPRMT6CYP2A6CYP2C19 | |
| SCHEMBL9839086 | 0.77 | ACHE (0.61) | ACHEBCHEPRMT6CYP2A6CYP2C19 | |
| SCHEMBL4999409 | 0.77 | ACHE (0.61) | ACHEBCHEPRMT6CYP2A6CYP2C19 | |
| SCHEMBL3453519 | 0.77 | ACHE (0.61) | ACHEBCHEPRMT6CYP2A6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117345-B1 | AMINOPYRIMIDINONES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-28 | — | — | EP | claimed |
| EP-0117345-A2 | Aminopyrimidinones as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-09-05 | — | — | EP | claimed |
| EP-0040696-A2 | Aminothiadiazoles as gastric secretion inhibitors | MERCK & CO. INC. (US) | 1981-12-02 | — | — | EP | claimed |
| US-5859030-A | Substituted arylalkylthioalkylthiopyridines for use in the control of helicobacter bacteria | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1999-01-12 | — | — | US | disclosed |
| US-5750714-A | Process for the manufacture of related intermediates including cistofur | BRANTFORD CHEMICALS INC. (CA) | 1998-05-12 | — | — | US | disclosed |
| EP-0764161-A1 | SUBSTITUTED ARYLALKYLTHIOALKYLTHIOPYRIDINES FOR USE IN THE CONTROL OF HELICOBACTER BACTERIA | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1997-03-26 | — | — | EP | disclosed |
| WO-1995034554-A1 | SUBSTITUTED ARYLALKYLTHIOALKYLTHIOPYRIDINES FOR USE IN THE CONTROL OF HELICOBACTER BACTERIA | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1995-12-21 | — | — | WO | disclosed |
| EP-0180298-B1 | PYRIMIDINE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-09-25 | — | — | EP | disclosed |
| EP-0150073-B1 | 3,4-DISUBSTITUTED-1,2,5-OXADIAZOLES HAVING HISTAMINE H2-RECEPTOR ANTAGONIST ACTIVITY | Bristol-Myers Squibb Company (US) | 1990-09-26 | — | — | EP | disclosed |
| EP-0117345-B1 | AMINOPYRIMIDINONES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-28 | — | — | EP | disclosed |
| EP-0134096-B1 | AMINOPYRIMIDINONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-01 | — | — | EP | disclosed |
| WO-1984004304-A1 | AMINOIMIDAZOLONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE FRENCH LAB (GB) | 1984-11-08 | — | — | WO | disclosed |
| EP-0117345-A2 | Aminopyrimidinones as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-09-05 | — | — | EP | disclosed |
| EP-0036716-B1 | PROCESS FOR PREPARING 5-DIMETHYLAMINOMETHYL-2-FURANMETHANOL | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-07-18 | — | — | EP | disclosed |
| US-4460506-A | Nitrovinyl aziridine derivative | GLAXO GROUP LIMITED (GB) | 1984-07-17 | — | — | US | disclosed |
| US-4440938-A | Process for the preparation of a furan derivative | GLAXO GROUP LIMITED (GB) | 1984-04-03 | — | — | US | disclosed |
| US-4413135-A | Intermediates in the preparation of ranitidine | GLAXO GROUP LIMITED (GB) | 1983-11-01 | — | — | US | disclosed |
| US-4347191-A | Process for the preparation of 5-dimethylaminomethyl-2-furanmethanol | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-08-31 | — | — | US | disclosed |
| EP-0040696-A2 | Aminothiadiazoles as gastric secretion inhibitors | MERCK & CO. INC. (US) | 1981-12-02 | — | — | EP | disclosed |
| EP-0036716-A1 | Process for preparing 5-dimethylaminomethyl-2-furanmethanol | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-09-30 | — | — | EP | disclosed |