Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.52 |
| ▸ | HRH2 | P25021 | 7/20 | 0.47 |
| ▸ | HRH1 | P35367 | 7/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8715690 | 0.94 | LTA4H (0.48) | LTA4HHRH3HRH2HRH1KCNJ1 | |
| SCHEMBL8409445 | 0.89 | CHRM4 (0.52) | LTA4HHRH3KDM1ACHRM4MAOA | |
| SCHEMBL8407650 | 0.84 | CHRM4 (0.56) | HRH3CHRM4MAOAMAOBSIGMAR1 | |
| SCHEMBL8409542 | 0.83 | MAOB (0.52) | LTA4HHRH3HRH2HRH1CHRM4 | |
| SCHEMBL6631280 | 0.82 | LTA4H (0.69) | LTA4HSIGMAR1 | |
| SCHEMBL6206626 | 0.82 | LTA4H (0.69) | LTA4HSIGMAR1 | |
| Hydrochloric Acid SCHEMBL8408022 | 0.81 | LTA4H (0.50) | LTA4HHRH3 | |
| SCHEMBL8407511 | 0.81 | MLNR (0.46) | LTA4HKDM1A | |
| SCHEMBL8409284 | 0.80 | KCNH2 (0.55) | LTA4HHRH3HRH2HRH1KCNJ1 | |
| SCHEMBL8407508 | 0.79 | HRH3 (0.49) | LTA4HHRH3HRH2HRH1KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |