Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.55 |
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.50 |
| ▸ | HRH2 | P25021 | 4/20 | 0.47 |
| ▸ | HRH1 | P35367 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407508 | 0.87 | HRH3 (0.49) | KCNH2KCNJ1HRH3HRH2HRH1 | |
| SCHEMBL14205445 | 0.81 | ALDH1A1 (0.64) | KCNH2THRATHRBHRH3HRH2 | |
| SCHEMBL4689543 | 0.81 | THRA (0.58) | THRATHRBHRH3HTR2AHTR2C | |
| SCHEMBL22470373 | 0.80 | ALDH1A1 (0.64) | THRATHRBHRH3HTR2AHTR2C | |
| SCHEMBL14495108 | 0.80 | HTR2A (0.67) | THRATHRBHRH2HRH1HTR2A | |
| SCHEMBL8410355 | 0.80 | LTA4H (0.54) | KCNH2KCNJ1HRH3HRH2HRH1 | |
| SCHEMBL18191776 | 0.80 | HTR2A (0.66) | THRATHRBHTR2AHDAC6LTA4H | |
| Hydrochloric Acid SCHEMBL8407181 | 0.80 | THRA (0.54) | THRATHRBHRH3HTR2AHTR2C | |
| SCHEMBL798078 | 0.78 | THRA (0.55) | KCNH2THRATHRBHTR2AHTR2C | |
| SCHEMBL3587044 | 0.78 | KCNH2 (0.60) | KCNH2KCNJ1HRH3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |