Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 7/20 | 0.55 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MDM4 | O15151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407115 | 0.80 | MDM4 (0.44) | CXCR2MEN1KMT2AALDH1A1GAA | |
| SCHEMBL8408918 | 0.79 | MEN1 (0.49) | CXCR2CXCR1MEN1KMT2AALDH1A1 | |
| SCHEMBL8409264 | 0.79 | ALDH1A1 (0.47) | CXCR2CXCR1MEN1KMT2AALDH1A1 | |
| SCHEMBL19927416 | 0.78 | CXCR2 (0.57) | CXCR2CXCR1MEN1KMT2ALMNA | |
| SCHEMBL14519906 | 0.77 | MEN1 (0.61) | CXCR2MEN1KMT2AALDH1A1MDM4 | |
| SCHEMBL1880282 | 0.75 | CXCR2 (0.70) | CXCR2CXCR1MEN1KMT2AALDH1A1 | |
| SCHEMBL8409970 | 0.74 | MDM4 (0.45) | MEN1KMT2AALDH1A1GAAMDM4 | |
| SCHEMBL12323597 | 0.74 | GAA (0.53) | MEN1KMT2AALDH1A1GAAMDM4 | |
| SCHEMBL14254797 | 0.74 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1LMNAGRM4 | |
| SCHEMBL14254815 | 0.74 | LMNA (0.62) | MEN1KMT2AALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994362-A | ADMINISTERING FINASTERIDE AND CASODEX | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0514056-A2 | Use of estrogens or antiandrogens for reversal of male sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016233-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |