Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410423 | 1.00 | TSHR (0.55) | TSHRHPGDHTTALDH1A1USP2 | |
| SCHEMBL8413516 | 1.00 | TSHR (0.55) | TSHRHPGDHTTALDH1A1USP2 | |
| SCHEMBL8998862 | 0.79 | HPGD (0.66) | TSHRHPGDHTTALDH1A1USP2 | |
| SCHEMBL29941835 | 0.79 | HPGD (0.66) | TSHRHPGDHTTALDH1A1USP2 | |
| SCHEMBL9729470 | 0.76 | ALDH1A1 (0.47) | ALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL31047712 | 0.75 | ALDH1A1 (0.49) | TSHRALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL11617650 | 0.75 | ALDH1A1 (0.49) | TSHRALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL3783840 | 0.74 | TSHR (0.51) | TSHRHPGDHTTALDH1A1USP2 | |
| SCHEMBL3783838 | 0.74 | TSHR (0.51) | TSHRHPGDHTTALDH1A1USP2 | |
| SCHEMBL27611795 | 0.74 | TSHR (0.51) | TSHRHPGDHTTALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880158-A | TREATMENT OF EPILEPSY AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS | RESEARCH CORPORATION TECH., INC. (US) | 1999-03-09 | — | — | US | disclosed |
| WO-1998013336-A1 | PROPIONAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1998-04-02 | — | — | WO | disclosed |