Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.38 |
| ▸ | RXRB | P28702 | 9/20 | 0.37 |
| ▸ | RXRG | P48443 | 6/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.35 |
| ▸ | PTGIR | P43119 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8411221 | 0.85 | RXRA (0.37) | RXRARXRBRXRGMRGPRX4MCL1 | |
| SCHEMBL8412763 | 0.83 | RXRA (0.35) | RXRARXRBRXRGMRGPRX4MCL1 | |
| SCHEMBL8413474 | 0.79 | TBXAS1 (0.33) | RXRARXRBRXRGMCL1PTGIR | |
| SCHEMBL8411148 | 0.79 | RXRA (0.39) | RXRARXRBRXRGMRGPRX4MCL1 | |
| SCHEMBL8414037 | 0.75 | RXRA (0.36) | RXRARXRBRXRGMRGPRX4MCL1 | |
| SCHEMBL8414350 | 0.73 | RXRA (0.42) | RXRARXRBRXRGMRGPRX4MCL1 | |
| SCHEMBL8414341 | 0.72 | MCL1 (0.35) | RXRARXRBRXRGMRGPRX4MCL1 | |
| SCHEMBL8411079 | 0.72 | RXRA (0.34) | RXRARXRBRXRGMRGPRX4MCL1 | |
| SCHEMBL8413511 | 0.72 | RXRA (0.34) | RXRARXRBRXRGMRGPRX4MCL1 | |
| SCHEMBL8410962 | 0.71 | RXRA (0.38) | RXRARXRBRXRGMRGPRX4MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962439-A | CARDIOVASCULAR DISORDER | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5849919-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |