SCHEMBL8411446

SCHEMBL8411446

O=C(O)C(CCn1cc(C(c2ccccc2)c2ccccc2)[nH]c1=O)Oc1cccc2c1CCC=C2

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 2/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8414311 0.84 MCL1 (0.36) PTGIRPTGDR2
SCHEMBL8410905 0.74 PTGIR (0.49) PTGIRPTGDR2
SCHEMBL8414455 0.71 CPB2 (0.35)
SCHEMBL8414123 0.71 C3AR1 (0.33) PTGIR
SCHEMBL8414339 0.71 PPARG (0.34) PTGIR
SCHEMBL8414351 0.70 PTGIR (0.30) PTGIR
SCHEMBL8411195 0.70 PTGIR (0.45) PTGIR
SCHEMBL8412747 0.69 PPARG (0.33) PTGIR
SCHEMBL8411434 0.69 PTGIR (0.32) PTGIR
SCHEMBL8411445 0.69 PTGIR (0.58) PTGIRPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5962439-A CARDIOVASCULAR DISORDER ONO PHARMACEUTICAL CO., LTD. (JP) 1999-10-05 US disclosed
US-5849919-A Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity ONO PHARMACEUTICAL CO., LTD. (JP) 1998-12-15 US disclosed