Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.46 |
| ▸ | HTR2C | P28335 | 6/20 | 0.46 |
| ▸ | HTR2B | P41595 | 4/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407021 | 0.82 | PNMT (0.40) | HTR2AHTR2CHTR2BPNMTHTR6 | |
| SCHEMBL5447372 | 0.77 | KDM4E (0.46) | HTR2AHTR2CHTR2BPNMTHTR6 | |
| SCHEMBL16518081 | 0.73 | KDM4E (0.46) | HTR2AHTR2CHTR2BPNMT | |
| SCHEMBL6191941 | 0.73 | HTR2C (0.51) | HTR2AHTR2CHTR2BPNMTHTR6 | |
| SCHEMBL29507128 | 0.72 | HTR2C (0.47) | HTR2AHTR2CHTR2BPNMT | |
| SCHEMBL22858683 | 0.72 | HTR2C (0.51) | HTR2AHTR2CHTR2BPNMT | |
| SCHEMBL22858977 | 0.72 | HTR2C (0.47) | HTR2AHTR2CHTR2BPNMT | |
| SCHEMBL29608060 | 0.72 | HTR2C (0.51) | HTR2AHTR2CHTR2BPNMT | |
| SCHEMBL16210365 | 0.72 | KMT2A (0.46) | HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL4012914 | 0.72 | CHRM3 (0.39) | HTR2AHTR2CHTR2BPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919794-A | Methods of using pharmaceutical tetrahydroisoquinolines | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1999-07-06 | — | — | US | disclosed |