Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.43 |
| ▸ | RXRB | P28702 | 9/20 | 0.43 |
| ▸ | RXRG | P48443 | 6/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8414280 | 0.82 | — | — | |
| SCHEMBL8410710 | 0.80 | RXRA (0.43) | RXRARXRBRXRGPTGESALOX5 | |
| SCHEMBL8411313 | 0.77 | POLB (0.42) | RXRARXRBRXRGPTGESALOX5 | |
| SCHEMBL9377874 | 0.75 | RXRA (0.49) | RXRARXRBRXRGPTGESALOX5 | |
| SCHEMBL13418809 | 0.74 | PPARG (0.51) | RXRARXRBRXRGPPARGPPARA | |
| SCHEMBL8520584 | 0.73 | RXRA (0.39) | RXRARXRBRXRGPTGESALOX5 | |
| SCHEMBL8414350 | 0.73 | RXRA (0.42) | RXRARXRBRXRGPTGESALOX5 | |
| SCHEMBL8564730 | 0.72 | RXRA (0.46) | RXRARXRBRXRGPTGESALOX5 | |
| SCHEMBL8564734 | 0.72 | RXRA (0.46) | RXRARXRBRXRGPTGESALOX5 | |
| SCHEMBL8414244 | 0.71 | RXRA (0.44) | RXRARXRBRXRGPTGESALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962439-A | CARDIOVASCULAR DISORDER | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5849919-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |