Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 6/20 | 0.37 |
| ▸ | RXRB | P28702 | 5/20 | 0.37 |
| ▸ | RXRG | P48443 | 5/20 | 0.37 |
| ▸ | RBP1 | P09455 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8413682 | 0.91 | POLB (0.43) | POLBPKMMEN1KMT2ANPSR1 | |
| SCHEMBL8411128 | 0.78 | ALDH1A1 (0.47) | NPSR1ALDH1A1NPC1LMNAGAA | |
| SCHEMBL8411148 | 0.78 | RXRA (0.39) | POLBKDM4ELMNARXRARXRB | |
| SCHEMBL8414044 | 0.77 | RXRA (0.43) | POLBALDH1A1KDM4ERXRARXRB | |
| SCHEMBL8414354 | 0.76 | RXRA (0.39) | POLBKDM4ELMNARXRARXRB | |
| SCHEMBL8412765 | 0.76 | RXRA (0.37) | POLBKDM4ELMNARXRARXRB | |
| SCHEMBL8413617 | 0.74 | HDAC1 (0.38) | POLBKDM4ELMNARXRARXRB | |
| SCHEMBL8354923 | 0.74 | PPARG (0.46) | POLBPKMMEN1KMT2ANPSR1 | |
| SCHEMBL8410887 | 0.74 | PTGIR (0.50) | RXRARXRBRXRGMCL1PTGES | |
| SCHEMBL8410710 | 0.73 | RXRA (0.43) | POLBALDH1A1KDM4ELMNARXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962439-A | CARDIOVASCULAR DISORDER | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | claimed |
| US-5962439-A | CARDIOVASCULAR DISORDER | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5849919-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |