Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | PRNP | P04156 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | PPARG | P37231 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.72 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.72 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18970426 | 0.87 | MAPT (0.78) | MAPTALDH1A1KDM4EGAALMNA | |
| SCHEMBL8412494 | 0.84 | NPSR1 (0.74) | MAPTALDH1A1KDM4EGAALMNA | |
| SCHEMBL18960346 | 0.82 | RXFP1 (0.76) | MAPTALDH1A1KDM4EGAALMNA | |
| SCHEMBL5453267 | 0.82 | RXFP1 (0.76) | MAPTALDH1A1KDM4EGAALMNA | |
| SCHEMBL3102501 | 0.82 | RXFP1 (0.76) | MAPTALDH1A1KDM4EGAALMNA | |
| Ammonia Solution, Strong SCHEMBL28931345 | 0.81 | RXFP1 (0.74) | MAPTALDH1A1KDM4EGAALMNA | |
| SCHEMBL5329456 | 0.80 | ALDH1A1 (0.67) | MAPTALDH1A1KDM4EGAALMNA | |
| SCHEMBL12726993 | 0.80 | BCKDK (0.68) | MAPTALDH1A1KDM4EGAALMNA | |
| SCHEMBL5584694 | 0.79 | MAPK1 (0.70) | MAPTALDH1A1KDM4EGAALMNA | |
| SCHEMBL18940219 | 0.79 | PRNP (0.70) | MAPTALDH1A1KDM4EGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5863936-A | HETEROCYCLIC ENZYME INHIBITORS AS ANTICANCER AGENTS | GERON CORPORATION (US) | 1999-01-26 | — | — | US | disclosed |
| US-5760062-A | ANTICANCER AGENTS | GERON CORPORATION (US) | 1998-06-02 | — | — | US | disclosed |
| US-5703116-A | TREATING CANCER | GERON CORPORATION (US) | 1997-12-30 | — | — | US | disclosed |