SCHEMBL8415427

SCHEMBL8415427

O=C(O)CCc1ccc(C2CNC(=O)N2CCC23CCN(CC2)CC3)cc1

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.35
CYP26B1 Q9NR63 3/20 0.34
CYP26A1 O43174 2/20 0.34
ITGB3 P05106 1/20 0.34
ITGA2B P08514 1/20 0.34
FFAR1 O14842 3/20 0.33
ATM Q13315 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
EPHX2 P34913 1/20 0.33
PARP1 P09874 1/20 0.32
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
KEAP1 Q14145 1/20 0.32
PPARD Q03181 1/20 0.32
PPARA Q07869 1/20 0.32
TBXAS1 P24557 1/20 0.32
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8414006 0.99 HRH3 (0.34) HRH3CYP26B1CYP26A1ITGB3ITGA2B
SCHEMBL8562091 0.77 HRH3 (0.39) HRH3ITGB3ITGA2BFFAR1ATM
SCHEMBL8414033 0.75 ITGB3 (0.51) HRH3ITGB3ITGA2BATM
Hydrochloric Acid SCHEMBL8413783 0.74 ITGB3 (0.50) ITGB3ITGA2BATM
Hydrochloric Acid SCHEMBL8417034 0.74 EPHX2 (0.35) HRH3CYP26B1CYP26A1ITGB3ITGA2B
Hydrochloric Acid SCHEMBL8875412 0.74 HRH3 (0.33) HRH3ITGB3ITGA2BFFAR1ATM
Hydrochloric Acid SCHEMBL8416948 0.74 ITGB3 (0.44) HRH3ITGB3ITGA2BFFAR1
Hydrochloric Acid SCHEMBL8417086 0.73 ITGB3 (0.36) HRH3ITGB3ITGA2BFFAR1PARP1
Hydrochloric Acid SCHEMBL8417109 0.71 ATM (0.42) ITGB3ITGA2BATM
SCHEMBL8415428 0.70 S1PR1 (0.56) ITGB3ITGA2BFFAR1PPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5880284-A HAVING ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASES-INHIBITING EFFECTS DR. KARL THOMAE GMBH (DE) 1999-03-09 US claimed
US-5681841-A PREVENTION CELL AGGREGATION KARL THOMAE GMBH (DE) 1997-10-28 US disclosed