Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.39 |
| ▸ | PPM1B | O75688 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1499484 | 0.79 | LOXL2 (0.48) | CACNA1BLOXL2CYP4F2CYP4A11PPM1B | |
| SCHEMBL10374052 | 0.79 | CYP4F2 (0.50) | LOXL2CYP4F2CYP4A11PPM1BALDH1A1 | |
| SCHEMBL9375934 | 0.79 | CYP4F2 (0.50) | LOXL2CYP4F2CYP4A11PPM1BALDH1A1 | |
| SCHEMBL9378795 | 0.79 | CYP4F2 (0.50) | LOXL2CYP4F2CYP4A11PPM1BALDH1A1 | |
| SCHEMBL8416867 | 0.77 | GRM2 (0.52) | LOXL2CYP4F2CYP4A11 | |
| SCHEMBL9384954 | 0.77 | ERN1 (0.40) | LOXL2CYP4F2CYP4A11PPM1BALDH1A1 | |
| SCHEMBL9377796 | 0.77 | ERN1 (0.40) | LOXL2CYP4F2CYP4A11PPM1BALDH1A1 | |
| SCHEMBL8415878 | 0.75 | HCRTR1 (0.43) | CACNA1BLOXL2CYP4F2CYP4A11PPM1B | |
| SCHEMBL8415880 | 0.75 | HCRTR1 (0.43) | CACNA1BLOXL2CYP4F2CYP4A11PPM1B | |
| SCHEMBL8418720 | 0.73 | LOXL2 (0.44) | LOXL2CYP4F2CYP4A11PPM1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990326-A | AN ANTIINFLAMMATORY AGENT AS INHIBITORS OF LEUKOTRIENE HYDROLASE | G.D. SEARLE & CO. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0360246-B1 | 3-Oxiranyl benzoic acids and derivatives thereof | SEARLE & CO (US) | 1994-03-30 | — | — | EP | disclosed |
| EP-0360246-A1 | 3-Oxiranyl benzoic acids and derivatives thereof | G.D. Searle & Co. (US) | 1990-03-28 | — | — | EP | disclosed |