Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.52 |
| ▸ | PNLIP | P16233 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | MDH1 | P40925 | 2/20 | 0.41 |
| ▸ | MGLL | Q99685 | 3/20 | 0.40 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8415822 | 0.86 | PLA2G4B (0.44) | CTSK | |
| SCHEMBL1499484 | 0.84 | LOXL2 (0.48) | LOXL2CYP4F2CYP4A11 | |
| SCHEMBL9375934 | 0.81 | CYP4F2 (0.50) | LOXL2CYP4F2CYP4A11 | |
| SCHEMBL9378795 | 0.81 | CYP4F2 (0.50) | LOXL2CYP4F2CYP4A11 | |
| SCHEMBL10374052 | 0.81 | CYP4F2 (0.50) | LOXL2CYP4F2CYP4A11 | |
| SCHEMBL8417241 | 0.78 | GRM2 (0.43) | GRM2LOXL2CYP4F2CYP4A11MDH1 | |
| SCHEMBL8417247 | 0.78 | GRM2 (0.43) | GRM2LOXL2CYP4F2CYP4A11MDH1 | |
| SCHEMBL8415879 | 0.77 | CACNA1B (0.40) | LOXL2CYP4F2CYP4A11 | |
| SCHEMBL3717973 | 0.77 | CA12 (0.47) | LOXL2CYP4F2CYP4A11 | |
| SCHEMBL8415858 | 0.75 | GRM2 (0.41) | GRM2LOXL2MDH1SLC10A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990326-A | AN ANTIINFLAMMATORY AGENT AS INHIBITORS OF LEUKOTRIENE HYDROLASE | G.D. SEARLE & CO. (US) | 1999-11-23 | — | — | US | claimed |
| EP-0360246-B1 | 3-Oxiranyl benzoic acids and derivatives thereof | SEARLE & CO (US) | 1994-03-30 | — | — | EP | claimed |
| EP-0360246-A1 | 3-Oxiranyl benzoic acids and derivatives thereof | G.D. Searle & Co. (US) | 1990-03-28 | — | — | EP | claimed |
| US-5990326-A | AN ANTIINFLAMMATORY AGENT AS INHIBITORS OF LEUKOTRIENE HYDROLASE | G.D. SEARLE & CO. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0360246-B1 | 3-Oxiranyl benzoic acids and derivatives thereof | SEARLE & CO (US) | 1994-03-30 | — | — | EP | disclosed |
| EP-0360246-A1 | 3-Oxiranyl benzoic acids and derivatives thereof | G.D. Searle & Co. (US) | 1990-03-28 | — | — | EP | disclosed |