Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 2/20 | 0.47 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.47 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668293 | 0.83 | SOAT2 (0.57) | SOAT1SOAT2ACAT1KMT2AALOX5 | |
| SCHEMBL5900901 | 0.83 | SOAT2 (0.57) | SOAT1SOAT2ACAT1KMT2AALOX5 | |
| SCHEMBL8042221 | 0.78 | SOAT2 (0.72) | SOAT1SOAT2ACAT1KMT2AKDM4E | |
| SCHEMBL8043457 | 0.76 | SOAT1 (0.47) | SOAT1SOAT2ACAT1MAPTALDH1A1 | |
| SCHEMBL8041447 | 0.76 | SOAT2 (0.47) | SOAT1SOAT2ACAT1MAPTALDH1A1 | |
| SCHEMBL8416085 | 0.76 | SOAT2 (0.44) | SOAT1SOAT2ACAT1KMT2AKDM4E | |
| SCHEMBL8042243 | 0.75 | SOAT2 (0.46) | SOAT1SOAT2ACAT1MAPTALDH1A1 | |
| SCHEMBL8049433 | 0.75 | SOAT2 (0.46) | SOAT1SOAT2ACAT1L3MBTL1MAPT | |
| SCHEMBL8417196 | 0.74 | SOAT2 (0.42) | SOAT1SOAT2ACAT1MAPTALDH1A1 | |
| SCHEMBL8859487 | 0.74 | KDM4E (0.43) | SOAT1KMT2AKDM4EL3MBTL1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990173-A | ANTICHOLESTEROL AGENTS; TREATING ATHEROSCLEROSIS; ENZYME INHIBITORS OF ACYLCOENZYME A:CHOLESTEROL ACYLTRANSFERASE (ACAT) | PIERRE FABRE MEDICAMENT (FR) | 1999-11-23 | — | — | US | disclosed |