Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.69 |
| ▸ | HTR1A | P08908 | 6/20 | 0.59 |
| ▸ | DRD2 | P14416 | 5/20 | 0.59 |
| ▸ | DRD4 | P21917 | 4/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | HRH2 | P25021 | 1/20 | 0.59 |
| ▸ | HTR1B | P28222 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8416326 | 0.87 | HSD17B10 (0.57) | KCNH2HTR1ADRD2DRD4HTR2A | |
| SCHEMBL8419627 | 0.87 | KCNH2 (0.71) | KCNH2HTR1ADRD2DRD4HTR2A | |
| SCHEMBL8416487 | 0.83 | KCNH2 (0.60) | KCNH2HTR1ADRD2DRD4HTR2A | |
| SCHEMBL4524281 | 0.82 | KCNH2 (1.00) | KCNH2HTR1ADRD2DRD4KDM4E | |
| SCHEMBL4525293 | 0.82 | KCNH2 (1.00) | KCNH2HTR1ADRD2DRD4HTR2A | |
| SCHEMBL8416458 | 0.81 | SIGMAR1 (0.59) | KCNH2HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL8416526 | 0.79 | HTR1A (0.62) | HTR1ADRD2DRD4HTR2AHTR7 | |
| SCHEMBL13711973 | 0.78 | KCNH2 (0.87) | KCNH2DRD2DRD4KDM4EALDH1A1 | |
| SCHEMBL10835591 | 0.78 | KCNH2 (0.81) | KCNH2HTR1ADRD2DRD4HTR2A | |
| SCHEMBL3198597 | 0.77 | KCNH2 (0.84) | KCNH2HTR1ADRD2DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655248-B1 | Use of 1-4-4-aryl(or heteroaryl)-1-piperazinylbutyl-1H-azole derivatives for the preparation of medicaments for the treatment of disorders of gastric secretion | ESTEVE LABOR DR (ES) | 1999-09-15 | — | — | EP | claimed |
| US-5532234-A | Use of 1-[4-[4-aryl (or heteroaryl)-1-piperazinyl]-butyl)-1H-azole derivatives for the preparation of medicaments intended for the treatment of disorders of gastric secretion | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 1996-07-02 | — | — | US | claimed |
| EP-0502786-B1 | Process for the preparation of aryl(or heteroaryl)-piperazin-1-butyl-azole derivatives | ESTEVE LABOR DR (ES) | 1996-04-24 | — | — | EP | claimed |
| EP-0497659-B1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | ESTEVE LABOR DR (ES) | 1996-04-10 | — | — | EP | claimed |
| EP-0497659-A1 | Aryl(or Heteroaryl)-piperazinyl-alkyl-azole derivatives, their preparation and their application as drugs | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-08-05 | — | — | EP | claimed |