Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4812741 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2PPARAPTGDR2KDM4ELMNA | |
| SCHEMBL8935855 | 0.81 | KDM4E (0.45) | SMN1; SMN2KDM4EL3MBTL1LMNAALDH1A1 | |
| SCHEMBL8935860 | 0.81 | KDM4E (0.45) | SMN1; SMN2KDM4EL3MBTL1LMNAALDH1A1 | |
| SCHEMBL27971306 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2PPARAPTGDR2L3MBTL1MAPK1 | |
| SCHEMBL4816920 | 0.78 | PPARA (0.59) | SMN1; SMN2PPARAPTGDR2KDM4ELMNA | |
| SCHEMBL2882636 | 0.77 | PTGDR2 (0.56) | SMN1; SMN2PPARAPTGDR2KDM4EL3MBTL1 | |
| SCHEMBL21057134 | 0.77 | PPARA (0.49) | SMN1; SMN2PPARAPTGDR2 | |
| SCHEMBL21057144 | 0.77 | PPARA (0.50) | SMN1; SMN2PPARAKDM4EL3MBTL1LMNA | |
| SCHEMBL21057136 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2PPARAPTGDR2LMNAMEN1 | |
| SCHEMBL21057133 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2PPARAPTGDR2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919793-A | QUINUCLIDINE DERIVATIVES, SQUALENE SYNTHETASE INHIBITORS, ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025459-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |