Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935855 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1ADRA2CADRA2AADRA2B | |
| SCHEMBL8935961 | 0.85 | SMN1; SMN2 (0.49) | ADRA2CADRA2AADRA2BLMNATSHR | |
| SCHEMBL5861928 | 0.85 | SMN1; SMN2 (0.49) | ADRA2CADRA2AADRA2BLMNATSHR | |
| SCHEMBL289123 | 0.82 | KMT2A (0.55) | KDM4EALDH1A1ADRA2CADRA2AADRA2B | |
| SCHEMBL3144299 | 0.82 | PPARA (0.50) | TSHRSMN1; SMN2 | |
| SCHEMBL8417754 | 0.81 | SMN1; SMN2 (0.42) | KDM4EALDH1A1LMNATDP1SMN1; SMN2 | |
| SCHEMBL11518243 | 0.79 | PPARG (0.49) | SMN1; SMN2L3MBTL1 | |
| SCHEMBL10449494 | 0.79 | ALDH1A1 (0.52) | KDM4EALDH1A1ADRA2CADRA2AADRA2B | |
| SCHEMBL9626061 | 0.79 | ADRA2C (0.53) | KDM4EALDH1A1ADRA2CADRA2AADRA2B | |
| SCHEMBL31112271 | 0.76 | ALDH1A1 (0.49) | KDM4EALDH1A1ADRA2CHTR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |