Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.51 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.51 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | HNF4A | P41235 | 1/20 | 0.47 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | HPN | P05981 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30910306 | 0.89 | NR1H4 (0.48) | HDAC1L3MBTL1NAMPTCA1CA2 | |
| SCHEMBL1205128 | 0.89 | NR1H4 (0.48) | HDAC1L3MBTL1NAMPTCA1CA2 | |
| SCHEMBL8417963 | 0.88 | HPN (0.49) | HDAC1L3MBTL1NAMPTCA1CA2 | |
| SCHEMBL14979282 | 0.87 | NR1H4 (0.50) | HDAC1L3MBTL1NAMPTCA1CA2 | |
| SCHEMBL30901987 | 0.87 | NR1H4 (0.50) | HDAC1L3MBTL1NAMPTCA1CA2 | |
| SCHEMBL5749285 | 0.85 | ERCC1 (0.56) | HDAC1LCKL3MBTL1NAMPTCA1 | |
| SCHEMBL1671124 | 0.85 | TSHR (0.55) | HDAC1L3MBTL1NAMPTNR1H4GAA | |
| SCHEMBL6625230 | 0.85 | NR1H4 (0.50) | HDAC1L3MBTL1NAMPTNR1H4GAA | |
| SCHEMBL474132 | 0.85 | ALDH1A1 (0.53) | HDAC1L3MBTL1NAMPTCA1CA2 | |
| SCHEMBL16415399 | 0.85 | HDAC1 (0.47) | HDAC1L3MBTL1NAMPTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922697-A | Compounds, compositions and methods for inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins | WARNER-LAMBERT COMPANY (US) | 1999-07-13 | — | — | US | disclosed |
| WO-1997012903-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING THE BINDING OF PROTEINS CONTAINING AN SH2 DOMAIN TO COGNATE PHOSPHORYLATED PROTEINS | WARNER-LAMBERT COMPANY (US) | 1997-04-10 | — | — | WO | disclosed |