SCHEMBL8418591

SCHEMBL8418591

C=CC(OC(C)OC(C=C)c1ccccc1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 5/20 0.35
MAPT P10636 4/20 0.35
CYP3A4 P08684 4/20 0.35
HPGD P15428 3/20 0.35
ALOX15 P16050 3/20 0.35
LMNA P02545 3/20 0.35
USP2 O75604 2/20 0.35
TP53 P04637 2/20 0.35
HSD17B10 Q99714 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
ALOX12 P18054 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
TAAR1 Q96RJ0 2/20 0.34
ADRA2A P08913 1/20 0.33
ADRA2C P18825 1/20 0.33
CYP2D6 P10635 1/20 0.33
HIF1A Q16665 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8419728 0.98 KDM4E (0.37) ALDH1A1KDM4EMAPTCYP3A4HPGD
SCHEMBL22654305 0.89 ALDH1A1 (0.33) ALDH1A1KDM4EMAPTCYP3A4HPGD
SCHEMBL15209920 0.88 ALDH1A1 (0.36) ALDH1A1KDM4EMAPTCYP3A4HPGD
SCHEMBL252297 0.87 CYP3A4 (0.37) ALDH1A1KDM4EMAPTCYP3A4HPGD
SCHEMBL28776501 0.86 LMNA (0.35) ALDH1A1MAPTLMNAMEN1KMT2A
SCHEMBL3298577 0.84 ALDH1A1 (0.34) ALDH1A1KDM4EMAPTCYP3A4HPGD
SCHEMBL3296386 0.84 TAAR1 (0.34) ALDH1A1KDM4EMAPTCYP3A4HPGD
SCHEMBL8711134 0.84 TAAR1 (0.34) ALDH1A1KDM4EMAPTCYP3A4HPGD
SCHEMBL8708905 0.84 LMNA (0.39) ALDH1A1KDM4ECYP3A4HPGDALOX15
SCHEMBL8419794 0.82 ALDH1A1 (0.40) ALDH1A1KDM4EMAPTCYP3A4HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0609061-B1 Polymerizable composition, polymer, organic glass and ophthalmic lens TOKUYAMA CORP (JP) 1999-09-29 EP claimed
US-5475074-A Copolamerizable monomers containing vinyl benzyl compound, 2,4-diphenyl-4-methyl-1-pentene and an acrylic momomer; also contains mercapto, hindered phenol and azo compounds; high refractive index, heat and radiation resistance TOKUYAMA CORPORATION (JP) 1995-12-12 US claimed
EP-0609061-A2 Polymerizable composition, polymer, organic glass and ophthalmic lens TOKUYAMA CORPORATION (JP) 1994-08-03 EP claimed
EP-0609061-B1 Polymerizable composition, polymer, organic glass and ophthalmic lens TOKUYAMA CORP (JP) 1999-09-29 EP disclosed
US-5475074-A Copolamerizable monomers containing vinyl benzyl compound, 2,4-diphenyl-4-methyl-1-pentene and an acrylic momomer; also contains mercapto, hindered phenol and azo compounds; high refractive index, heat and radiation resistance TOKUYAMA CORPORATION (JP) 1995-12-12 US disclosed
EP-0609061-A2 Polymerizable composition, polymer, organic glass and ophthalmic lens TOKUYAMA CORPORATION (JP) 1994-08-03 EP disclosed