SCHEMBL8419353

SCHEMBL8419353

Fc1cc(C2CCC(CCC3CC[SiH](Cl)CC3)CC2)cc(F)c1Cl

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
OPRL1 P41146 9/20 0.33
ESR2 Q92731 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8419351 1.00 OPRL1 (0.33) OPRL1ESR2
SCHEMBL8417344 0.89 ESR2 (0.32) OPRL1ESR2
SCHEMBL8417346 0.89 ESR2 (0.32) OPRL1ESR2
SCHEMBL8418649 0.84 ESR2 (0.36) OPRL1ESR2
SCHEMBL8418650 0.84 ESR2 (0.36) OPRL1ESR2
SCHEMBL8419377 0.81 GRM2 (0.31)
SCHEMBL8419381 0.81 GRM2 (0.31)
SCHEMBL7762619 0.80 OPRL1 (0.35) OPRL1ESR2
SCHEMBL7762611 0.80 OPRL1 (0.35) OPRL1ESR2
SCHEMBL8419346 0.79 OPRL1 (0.31) OPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648773-B1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHINETSU CHEMICAL CO (JP) 1999-09-08 EP disclosed
US-5547606-A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-08-20 US disclosed
EP-0648773-A1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it Shin-Etsu Chemical Co., Ltd. (JP) 1995-04-19 EP disclosed